NFL Week 2 Preview and Predictions (2022)

Each week we write a preview for each game include NFL bet predictions and some narratives to consider. Whether you are looking for the best NFL bets or looking to decide which players to site in your fantasy football league, this article will help keep you informed.

Without further adieu, enjoy our Week 2 NFL Game preview…

Los Angeles Chargers vs. Kansas City Chiefs

Kickoff: Thursday, September 15 at 8:15 PM EST

Point Spread: 4.0

Over/Under Game Total: 54.0

The Los Angeles Chargers will face off against the Kansas City Chiefs at Arrowhead Stadium this week. The Chiefs are favorites at home, getting 4.0 points from Vegas.

Justin Herbert will lead The Chargers on the offense. Last week Herbert went 26 for 34 pass completions for nearly 280 yards. This week Herbert should be able to exceed last week’s passing performance. Last week, The Chiefs allowed almost 180 passing yards and gave up over 10 first downs by passing. The Kansas City Chiefs will likely be looking to attack Justin Herbert in the pocket. Herbert should be able to use his speed and agility to run the ball himself.

Austin Ekeler will carry the majority of the run game for The Chargers. Last week Ekeler had over 2.0 yards per carry and should be able to well exceed that pace.

Mike Williams, Joshua Palmer, DeAndre Carter, and Gerald Everett will be responsible for receiving for The Chargers. Mike Williams had 2.0 receptions last week but should see much more usage in this matchup. Joshua Palmer had nearly 2.0 receptions in week one but should see much more use in this matchup. Last week DeAndre Carter had 4.0 targets; his usage should be higher this week, and he should be able to connect much more. Gerald Everett had nearly 2.0 receptions last week but should see much more use in this matchup.

Patrick Mahomes will lead The Chiefs on the offense. Last week Mahomes went 30 for 39 pass completions for 360 yards. This week Mahomes will likely struggle with the passing game against this defense. Last week, The Chargers allowed nearly 260 passing yards and gave up almost 20 first downs by passing. The Los Angeles Chargers will likely be looking to put pressure on Patrick Mahomes in the pocket. Mahomes should be able to use his speed and mobility to run the ball himself.

Clyde Edwards-Helaire will carry the majority of the run game for The Chiefs. Last week Edwards-Helaire had 6 yards per carry and should be able to keep up with that pace.

The Chiefs will have Travis Kelce, JuJu Smith-Schuster, Marquez Valdes-Scantling, and Mecole Hardman handling the receiving. Mecole Hardman had over 2.0 receptions last week but should see more usage in this matchup.

Carolina Panthers vs. New York Giants

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 2.0

Over/Under Game Total: 43.5

This week, the Carolina Panthers will face off against the New York Giants at MetLife Stadium. The Giants are favorites at home, getting 2.0 points from Vegas.

Baker Mayfield will lead The Panthers on the offense. Last week Mayfield went 16 for 27 pass completions for 235 yards. This week Mayfield should be able to keep up with last week’s passing performance. Last week, The Giants allowed nearly 270 passing yards and gave up over 10 first downs by passing. Mayfield will be able to utilize his legs and scramble out of any danger when necessary.

Christian McCaffrey will carry the majority of the run game for The Panthers. Last week McCaffrey had nearly 4.0 yards per carry and should be able to well exceed that pace.

DJ Moore, Christian McCaffrey, Robbie Anderson, and Shi Smith will be responsible for receiving for The Panthers. Last week DJ Moore had 6.0 targets; his usage should be higher this week, and he should be able to connect much more. In addition to running the ball, Christian McCaffrey will also be involved in the passing game. Last week, McCaffrey had over 4 targets and should expect a similar number of looks this week. Last week Shi Smith had around 2.0 targets; his usage should be higher this week, and he should be able to connect much more.

Daniel Jones will lead The Giants on the offense. Last week Jones went 17 for 21 pass completions for nearly 190 yards. This week Jones should be able to exceed last week’s passing performance. Last week, The Panthers allowed almost 140 passing yards and gave up nearly 10 first downs by passing. Jones should be able to use his speed and mobility to run the ball himself.

Saquon Barkley will carry the majority of the run game for The Giants.

The passing game for The Giants will be handled by Sterling Shepard, Kenny Golladay, Saquon Barkley, and Richie James Jr.. Sterling Shepard had 2.0 receptions last week but should see much more usage in this matchup. Last week Kenny Golladay had 2.0 targets; his use should be higher this week and be able to connect much more. In addition to running the ball, Saquon Barkley will also be involved in the passing game. Last week, Barkley had nearly 6 targets and should expect a similar number of looks this week.

Tampa Bay Buccaneers vs. New Orleans Saints

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 2.5

Over/Under Game Total: 44.0

The Tampa Bay Buccaneers will face off against the New Orleans Saints at Caesars Superdome this week. The Buccaneers are favorites on the road, getting 2.5 points from Vegas.

Tom Brady will lead The Buccaneers on the offense. Last week Brady went 18 for 27 pass completions for over 210 yards. This week Brady should be able to exceed last week’s passing performance. Last week, The Saints allowed over 210 passing yards and gave up nearly 10 first downs by passing.

Leonard Fournette will carry the majority of the run game for The Buccaneers.

The Buccaneers will have Mike Evans, Julio Jones, Russell Gage, and Leonard Fournette handling the receiving. Mike Evans had over 4.0 receptions last week and should see a similar amount of usage in this matchup. Last week Julio Jones had nearly 4.0 targets; his use should be higher this week, and he should be able to connect much more. Last week Russell Gage had 2.0 targets; his usage should be higher this week, and he should be able to connect much more. In addition to running the ball, Leonard Fournette will also be involved in the passing game. Last week, Fournette had 2 targets and should expect a similar number of looks this week.

Jameis Winston will lead The Saints on the offense. Last week Winston went 23 for 34 pass completions for nearly 270 yards. This week Winston should be able to keep up with last week’s passing performance. Last week, The Buccaneers allowed over 170 passing yards and gave up nearly 10 first downs by passing. The Tampa Bay Buccaneers will likely be looking to attack Jameis Winston in the pocket. Winston should be able to use his speed and mobility to run the ball himself.

Alvin Kamara will carry the majority of the run game for The Saints. Last week Kamara had nearly 4.0 yards per carry and should be able to well exceed that pace.

Michael Thomas, Jarvis Landry, Chris Olave, and Alvin Kamara will be responsible for receiving for The Saints. Michael Thomas had nearly 4.0 receptions last week and should see a similar amount of usage in this matchup. Last week Chris Olave saw over 2.0 targets. Ideally, he’ll get about the same number of looks this week. In addition to running the ball, Alvin Kamara will also be involved in the passing game. Last week, Kamara had 4 targets and should expect a similar number of looks this week.

New York Jets vs. Cleveland Browns

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 6.5

Over/Under Game Total: 39.5

The New York Jets will face off against the Cleveland Browns at FirstEnergy Stadium this week. The Browns are favorites at home, getting 6.5 points from Vegas.

Joe Flacco will lead The Jets on the offense. Last week Flacco went 37 for 59 pass completions for nearly 310 yards. This week Flacco will likely struggle with the passing game against this defense. Last week, The Browns allowed nearly 210 passing yards and gave up almost 10 first downs by passing. The Cleveland Browns will likely be looking to attack Joe Flacco in the pocket.

The Jets will have a split backfield with Michael Carter and Breece Hall sharing responsibilities of the run game.

The passing game for The Jets will be handled by Elijah Moore, Corey Davis, Garrett Wilson, and Tyler Conklin.

Jacoby Brissett will lead The Browns on the offense. Last week Brissett went 18 for 34 pass completions for nearly 145 yards. This week Brissett should be able to exceed last week’s passing performance. Last week, The Jets allowed over 210 passing yards and gave up nearly 10 first downs by passing. The New York Jets will likely be looking to attack Jacoby Brissett in the pocket. Brissett should be able to use his speed and agility to run the ball himself.

Nick Chubb will carry the majority of the run game for The Browns.

The Browns will have Amari Cooper, Donovan Peoples-Jones, David Njoku, and Harrison Bryant handling the receiving. Amari Cooper had nearly 2.0 receptions last week, but this matchup should see much more usage. Last week David Njoku had over 0.0 targets. His use should be higher this week, and he will be able to connect much more.

Miami Dolphins vs. Baltimore Ravens

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 3.5

Over/Under Game Total: 44.5

The Miami Dolphins will face off against the Baltimore Ravens at M&T Bank Stadium this week. The Ravens are favorites at home, getting 3.5 points from Vegas.

Tua Tagovailoa will lead The Dolphins on the offense. Last week Tagovailoa went 23 for 33 pass completions for 270 yards. This week Tagovailoa will likely struggle with the passing game against this defense. Last week, The Ravens allowed almost 300 passing yards and gave up nearly 20 first downs by passing. The Baltimore Ravens will likely be looking to put pressure on Tua Tagovailoa in the pocket. Tagovailoa will be able to utilize his legs and scramble out of any danger when necessary.

Chase Edmonds will carry the majority of the run game for The Dolphins. Last week Edmonds had over 2.0 yards per carry and should be able to well exceed that pace.

The Dolphins will have Tyreek Hill, Jaylen Waddle, Mike Gesicki, and Cedrick Wilson Jr. handling the receiving. Last week Jaylen Waddle had over 4.0 targets. His usage should be higher this week, and he should be able to connect much more. Mike Gesicki had nearly 0.0 receptions last week but should see much more usage in this matchup. Cedrick Wilson Jr. had 2.0 receptions last week and should see a similar amount of usage in this matchup.

Lamar Jackson will lead The Ravens on the offense. Last week Jackson went 17 for 30 pass completions for almost 215 yards. This week Jackson should be able to exceed last week’s passing performance. Last week, The Dolphins allowed nearly 190 passing yards and gave up 10 first downs by passing. The Miami Dolphins will likely be looking to attack Lamar Jackson in the pocket. Jackson should be able to use his speed and agility to run the ball himself.

J.K. Dobbins will carry the majority of the run game for The Ravens. Last week Dobbins had 0 yards per carry and should be able to well exceed that pace.

The passing game for The Ravens will be handled by Mark Andrews, Rashod Bateman, Devin Duvernay, and Isaiah Likely. Mark Andrews had nearly 4.0 receptions last week but should see much more usage in this matchup. Rashod Bateman had 2.0 receptions last week but should see more usage in this matchup. Last week Isaiah Likely had 4.0 targets; his usage should be higher this week, and he should be able to connect much more.

New England Patriots vs. Pittsburgh Steelers

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 2.0

Over/Under Game Total: 40.5

The New England Patriots will face off against the Pittsburgh Steelers at Acrisure Stadium this week. The Patriots are favorites on the road, getting 2.0 points from Vegas.

Mac Jones will lead The Patriots on the offense. Last week Jones went 21 for 30 pass completions for nearly 215 yards.

After the Patriots’ disappointing 20-7 loss at Hard Rock Stadium, last week Mac Jones exited the field with medical personnel to get an X-ray done. All signs and reports show that Mac Jones is healthy and should be suited up on Sunday.

If Jones cannot play due to a setback, then Brian Hoyer and Bailey Zappe are next on the depth chart. But this is hopefully a non-issue.

Assuming he plays this week, Mac Jones should be able to exceed last week’s passing performance. Last week, The Steelers allowed almost 300 passing yards and gave up nearly 20 first downs by passing. The Pittsburgh Steelers will likely be looking to attack Mac Jones in the pocket and keep high pressure on a banged up quarterback. Jones will be able to utilize his legs and scramble out of any danger when necessary.

The Patriots will have a split backfield with Damien Harris and Rhamondre Stevenson sharing responsibilities of the run game.

The Patriots will have Jakobi Meyers, DeVante Parker, Hunter Henry, and Nelson Agholor handling the receiving. Last week Jakobi Meyers had 6.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week DeVante Parker had 2.0 targets; his usage should be higher this week. Last week Hunter Henry had over 2.0 targets.

Mitch Trubisky will lead The Steelers on the offense. Last week Trubisky went 21 for 38 pass completions for almost 195 yards. This week Trubisky should be able to exceed last week’s passing performance. Last week, The Patriots allowed over 240 passing yards and gave up nearly 10 first downs by passing. The New England Patriots will likely be looking to put pressure on Mitch Trubisky in the pocket. Trubisky should be able to use his speed and agility to run the ball himself.

Najee Harris will carry the majority of the run game for The Steelers. Last week Harris had nearly 2.0 yards per carry and should be able to well exceed that pace.

Diontae Johnson, Chase Claypool, Pat Freiermuth, and George Pickens will be responsible for receiving for The Steelers. In addition to running the ball, Chase Claypool will also be involved in the passing game. Last week Claypool saw 6 targets and should see a similar number of looks this week. George Pickens had over 0.0 receptions last week but should see much more usage in this matchup.

Washington Commanders vs. Detroit Lions

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 1.5

Over/Under Game Total: 48.5

The Washington Commanders will face off against the Detroit Lions at Ford Field this week. The Lions are favorites at home, getting 1.5 points from Vegas.

Carson Wentz will lead The Commanders on the offense. Last week Wentz went 27 for 41 pass completions for nearly 315 yards. Last week, The Lions allowed almost 240 passing yards and gave up over 10 first downs by passing. This week Wentz will likely struggle with the passing game against this defense. Wentz should be able to use his speed and agility to run the ball himself.

Antonio Gibson will carry the majority of the run game for The Commanders. Last week Gibson had over 4.0 yards per carry and should be able to keep up with that pace.

Terry McLaurin, Curtis Samuel, Jahan Dotson, and Logan Thomas will be responsible for receiving for The Commanders. Terry McLaurin had 2.0 receptions last week but should see much more usage in this matchup. Last week Jahan Dotson had nearly 4.0 targets, his usage should be higher this week, and he should be able to connect much more. Last week Logan Thomas saw 6.0 targets. Ideally, he’ll get about the same number of looks this week.

The Washington Commanders will likely be looking to attack Jared Goff in the pocket. Jared Goff will lead The Lions on the offense. Last week Goff went 21 for 37 pass completions for 215 yards. This week Goff should be able to exceed last week’s passing performance. Last week, The Commanders allowed 260 passing yards and gave up nearly 10 first downs by passing.

D’Andre Swift will carry the majority of the run game for The Lions.

Amon-Ra St. Brown, T.J. Hockenson, DJ Chark Jr., and Josh Reynolds will handle the passing game for The Lions. Last week T.J. Hockenson saw over 6.0 targets. Ideally, he’ll get about the same number of looks this week. Last week Josh Reynolds had nearly 2.0 targets; his usage should be higher this week, and he should be able to connect much more.

Indianapolis Colts vs. Jacksonville Jaguars

Kickoff: Sunday, September 18 at 1:00 PM EST

Point Spread: 4.0

Over/Under Game Total: 45.5

The Indianapolis Colts will face off against the Jacksonville Jaguars at TIAA Bank Field this week. The Colts are favorites on the road, getting 4.0 points from Vegas.

Matt Ryan will lead The Colts on the offense. Last week Ryan went 32 for 50 pass completions for nearly 350 yards. This week Ryan will likely struggle with the passing game against this defense. Last week, The Jaguars allowed almost 300 passing yards and gave up nearly 20 first downs by passing. Ryan will be able to utilize his legs and scramble out of any danger when necessary.

Jonathan Taylor will carry the majority of the run game for The Colts.

The passing game for The Colts will be handled by Michael Pittman Jr., Parris Campbell, Alec Pierce, and Ashton Dulin. Alec Pierce had 0.0 receptions last week but ideally he’ll step up and play a bigger role this week.

Trevor Lawrence will lead The Jaguars on the offense. Last week Lawrence went 24 for 42 pass completions for 275 yards. This week Lawrence will likely struggle with the passing game against this defense. Last week, The Colts allowed over 220 passing yards and gave up nearly 10 first downs by passing. The Indianapolis Colts will likely be looking to attack Trevor Lawrence in the pocket. Lawrence should be able to use his speed and agility to run the ball himself.

James Robinson will carry the majority of the run game for The Jaguars.

The Jaguars will have Christian Kirk, Marvin Jones Jr., Zay Jones, and Evan Engram handling the receiving. Last week Marvin Jones Jr. saw 6.0 targets; ideally, he’ll get about the same number of looks this week.

Atlanta Falcons vs. Los Angeles Rams

Kickoff: Sunday, September 18 at 4:05 PM EST

Point Spread: 10.0

Over/Under Game Total: 47.0

The Atlanta Falcons will face off against the Los Angeles Rams at SoFi Stadium this week. The Rams are favorites at home, getting 10.0 points from Vegas.

Marcus Mariota will lead The Falcons on the offense. Last week Mariota went 20 for 33 pass completions for 215 yards. This week Mariota should be able to keep up with last week’s passing performance. Last week, The Rams allowed nearly 290 passing yards and gave up over 10 first downs by passing. The Los Angeles Rams will likely be looking to attack Marcus Mariota in the pocket. Mariota should be able to use his speed and agility to run the ball himself.

Cordarrelle Patterson will carry the majority of the run game for The Falcons.

Kyle Pitts, Drake London, Cordarrelle Patterson, and Olamide Zaccheaus will be responsible for receiving for The Falcons. Last week Kyle Pitts had over 6.0 targets. His usage should be higher this week, and he should be able to connect much more. In addition to running the ball, Cordarrelle Patterson will also be involved in the passing game. Last week Patterson saw over 4 targets and should see a similar number of looks this week. In addition to running the ball, Olamide Zaccheaus will also be involved in the passing game. Last week, Zaccheaus had 4 targets and should expect a similar number of looks this week.

Matthew Stafford will lead The Rams on the offense. Last week Stafford went 29 for 41 pass completions for 240 yards. This week Stafford should be able to exceed last week’s passing performance. Last week, The Falcons allowed nearly 230 passing yards and gave up almost 10 first downs by passing. The Atlanta Falcons will likely be looking to put pressure on Matthew Stafford in the pocket. Stafford will be able to utilize his legs and scramble out of any danger when necessary.

Darrell Henderson Jr. will carry the majority of the run game for The Rams. Last week Jr. had nearly 4.0 yards per carry and should be able to well exceed that pace.

Cooper Kupp, Allen Robinson II, Tyler Higbee, and Darrell Henderson Jr. will handle the passing game for The Rams. Last week, Allen Robinson II had 2.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week Tyler Higbee saw nearly 10.0 targets. Ideally, he’ll get about the same number of looks this week. In addition to running the ball, Darrell Henderson Jr. will also be involved in the passing game. Last week, Jr. had nearly 4 targets and should expect a similar number of looks this week.

Seattle Seahawks vs. San Francisco 49ers

Kickoff: Sunday, September 18 at 4:05 PM EST

Point Spread: 9.0

Over/Under Game Total: 42.0

The Seattle Seahawks will face off against the San Francisco 49ers at Levi’s Stadium this week. The 49ers are favorites at home, getting 9.0 points from Vegas.

Geno Smith will lead The Seahawks on the offense. Last week Smith went 23 for 28 pass completions for 195 yards. This week Smith should be able to keep up with last week’s passing performance. Last week, The 49ers allowed nearly 100 passing yards and gave up nearly 0 first downs by passing. The San Francisco 49ers will likely be looking to attack Geno Smith in the pocket. Smith should be able to use his speed and agility to run the ball himself.

Rashaad Penny will carry the majority of the run game for The Seahawks.

The passing game for The Seahawks will be handled by DK Metcalf, Tyler Lockett, and Noah Fant. Last week Tyler Lockett had 4.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week Noah Fant saw 4.0 targets. Ideally, he’ll get about the same number of looks this week.

Trey Lance will lead The 49ers on the offense. Last week Lance went 13 for 28 pass completions for nearly 165 yards. This week Lance should be able to exceed last week’s passing performance. Last week, The Seahawks allowed 330 passing yards and gave up nearly 10 first downs by passing. The Seattle Seahawks will likely be looking to put pressure on Trey Lance in the pocket. Lance should be able to use his speed and mobility to run the ball himself.

Jeff Wilson Jr. will carry most of the run game for The 49ers. Last week Jr. had over 2.0 yards per carry and should be able to well exceed that pace.

The passing game for The 49ers will be handled by Deebo Samuel, Brandon Aiyuk, George Kittle, and Jauan Jennings. In addition to running the ball, Deebo Samuel will also be involved in the passing game. Last week Samuel saw nearly 6 targets and should see a similar number of looks this week. Brandon Aiyuk had 2.0 receptions last week but should see much more usage in this matchup. George Kittle had 0.0 receptions last week but should see much more usage in this matchup.

Arizona Cardinals vs. Las Vegas Raiders

Kickoff: Sunday, September 18 at 4:25 PM EST

Point Spread: 5.5

Over/Under Game Total: 51.5

This week, the Arizona Cardinals will face off against the Las Vegas Raiders at Allegiant Stadium. The Raiders are favorites at home, getting 5.5 points from Vegas.

Kyler Murray will lead The Cardinals on the offense. Last week Murray went 22 for 34 pass completions for almost 195 yards. This week Murray should be able to exceed last week’s passing performance. Last week, The Raiders allowed nearly 280 passing yards and gave up nearly 10 first downs by passing. Murray should be able to use his speed and mobility to run the ball himself.

James Conner will carry the majority of the run game for The Cardinals. Last week Conner had nearly 2.0 yards per carry and should be able to well exceed that pace.

The passing game for The Cardinals will be handled by Marquise Brown, A.J. Green, Zach Ertz, and Greg Dortch. Marquise Brown had 4.0 receptions last week but should see much more usage in this matchup. A.J. Green had 2.0 receptions last week but should see much more usage in this matchup. Zach Ertz had 2.0 receptions last week but should see more usage in this matchup.

Derek Carr will lead The Raiders on the offense. Last week Carr went 22 for 37 pass completions for 295 yards. This week Carr should be able to exceed last week’s passing performance. Last week, The Cardinals allowed 360 passing yards and gave up nearly 20 first downs by passing. Carr will be able to utilize his legs and scramble out of any danger when necessary.

Josh Jacobs will carry the majority of the run game for The Raiders. Last week Jacobs had nearly 6.0 yards per carry and should be able to well exceed that pace.

The passing game for The Raiders will be handled by Davante Adams, Hunter Renfrow, Darren Waller, and Mack Hollins. Last week Hunter Renfrow had 6.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week Darren Waller had 6.0 targets, his usage should be higher this week, and he should be able to connect much more. Last week Mack Hollins had nearly 0.0 targets. His usage should be higher this week, and he should be able to connect much more.

Cincinnati Bengals vs. Dallas Cowboys

Kickoff: Sunday, September 18 at 4:25 PM EST

Point Spread: 7.0

Over/Under Game Total: 41.5

The Cincinnati Bengals will face off against the Dallas Cowboys at AT&T Stadium this week. The Bengals are favorites on the road, getting 7.0 points from Vegas.

Joe Burrow will lead The Bengals on the offense. Last week Burrow went 33 for 53 pass completions for nearly 340 yards. This week Burrow will likely struggle with the passing game against this defense. Last week, The Cowboys allowed nearly 190 passing yards and gave up nearly 10 first downs by passing. The Dallas Cowboys will likely be looking to put pressure on Joe Burrow in the pocket. Burrow will be able to utilize his legs and scramble out of any danger when necessary.

Joe Mixon will carry the majority of the run game for The Bengals. Last week Mixon had nearly 2.0 yards per carry and should be able to keep up with that pace.

Ja’Marr Chase, Tee Higgins, Tyler Boyd, and Hayden Hurst will be responsible for receiving for The Bengals. Last week Tee Higgins had 2.0 targets, his usage should be higher this week, and he should be able to connect much more. Tyler Boyd had 4.0 receptions last week and should see a similar amount of usage in this matchup.

Cooper Rush will lead The Cowboys on the offense after Dak Prescott went down during last week’s game, he’ll be out for at least a few weeks. Last week Rush went 7 for 13 pass completions for nearly 65 yards. Last week, The Bengals allowed nearly 190 passing yards and gave up almost 10 first downs by passing. Rush will be able to utilize his legs and scramble out of any danger when necessary.

Ezekiel Elliott will carry the majority of the run game for The Cowboys.

The Cowboys will have CeeDee Lamb, Dalton Schultz, Noah Brown, and Simi Fehoko handling the receiving. Last week CeeDee Lamb had nearly 10.0 targets. His usage should be higher this week, and he should be able to connect much more.

Houston Texans vs. Denver Broncos

Kickoff: Sunday, September 18 at 4:25 PM EST

Point Spread: 10.0

Over/Under Game Total: 45.0

The Houston Texans will face off against the Denver Broncos at Empower Field at Mile High this week. The Broncos are favorites at home, getting 10.0 points from Vegas.

Davis Mills will lead The Texans on the offense. Last week Mills went 23 for 37 pass completions for 240 yards. This week Mills will likely struggle with the passing game against this defense. Last week, The Broncos allowed nearly 180 passing yards and gave up almost 10 first downs by passing. The Denver Broncos will likely be looking to attack Davis Mills in the pocket.

The Texans will have a split backfield with Rex Burkhead and Dameon Pierce sharing responsibilities of the run game.

The Texans will have Brandin Cooks, Nico Collins, Chris Moore, and Brevin Jordan handling the receiving. Last week Nico Collins had nearly 2.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week Brevin Jordan had 2.0 targets; his usage should be higher this week, and he should be able to connect much more.

Russell Wilson will lead The Broncos on the offense. Last week Wilson went 29 for 42 pass completions for 340 yards. This week Wilson will likely struggle with the passing game against this defense. Last week, The Texans allowed 340 passing yards and gave up 20 first downs by passing. The Houston Texans will likely be looking to put pressure on Russell Wilson in the pocket. Wilson should be able to use his speed and agility to run the ball himself.

The Broncos will have a split backfield with Javonte Williams and Melvin Gordon III sharing responsibilities of the run game.

Courtland Sutton, Jerry Jeudy, Albert Okwuegbunam, and Javonte Williams will be responsible for receiving for The Broncos. Last week Courtland Sutton had over 6.0 targets. His usage should be higher this week, and he should be able to connect much more. Jerry Jeudy had 4.0 receptions last week and should see a similar amount of usage in this matchup. In addition to running the ball, Javonte Williams will also be involved in the passing game. Last week, Williams had 12 targets and should expect a similar number of looks this week.

Chicago Bears vs. Green Bay Packers

Kickoff: Sunday, September 18 at 8:20 PM EST

Point Spread: 10.0

Over/Under Game Total: 41.5

The Chicago Bears will face off against the Green Bay Packers at Lambeau Field this week. The Packers are favorites at home, getting 10.0 points from Vegas.

Justin Fields will lead The Bears on the offense. Last week Fields went 8 for 17 pass completions for over 120 yards. This week Fields should be able to exceed last week’s passing performance. Last week, The Packers allowed nearly 270 passing yards and gave up nearly 10 first downs by passing. Fields should be able to use his speed and agility to run the ball himself.

David Montgomery will carry the majority of the run game for The Bears. Last week Montgomery had almost 2.0 yards per carry and should be able to well exceed that pace.

The Bears will have Darnell Mooney, Cole Kmet, Equanimeous St. Brown, and David Montgomery handling the receiving. Darnell Mooney had over 0.0 receptions last week but should see much more usage in this matchup. Cole Kmet had 0.0 receptions last week but should see much more usage in this matchup. Last week Equanimeous St. Brown had nearly 2.0 targets, his usage should be higher this week, and he should be able to connect much more. In addition to running the ball, David Montgomery will also be involved in the passing game. Last week Montgomery saw 4 targets and should see a similar number of looks this week.

The Chicago Bears will likely be looking to attack Aaron Rodgers in the pocket. Aaron Rodgers will lead The Packers on the offense. Last week Rodgers went 22 for 34 pass completions for 195 yards. This week Rodgers should be able to exceed last week’s passing performance. Last week, The Bears allowed nearly 150 passing yards and gave up nearly 0 first downs by passing. 

Despite the tough start for the Packers, Rodgers is the back-to-back MVP and is ready to bounce back. 

Rodgers will be able to utilize his legs and scramble out of any danger when necessary.

The Packers will have a split backfield with AJ Dillon and Aaron Jones sharing responsibilities of the run game.

The passing game for The Packers will be handled by Allen Lazard, Aaron Jones, Robert Tonyan, and Sammy Watkins. Last week Allen Lazard had 0.0 targets, his usage should be higher this week, and he should be able to connect much more. In addition to running the ball, Aaron Jones will also be involved in the passing game. Last week, Jones had nearly 4 targets and should expect a similar number of looks this week. Robert Tonyan had nearly 2.0 receptions last week and should see a similar amount of usage in this matchup.

Tennessee Titans vs. Buffalo Bills

Kickoff: Monday, September 19 at 7:15 PM EST

Point Spread: 10.0

Over/Under Game Total: 48.5

This week, the Tennessee Titans will face off against the Buffalo Bills at Highmark Stadium. The Bills are favorites at home, getting 10.0 points from Vegas.

Ryan Tannehill will lead The Titans on the offense. Last week Tannehill went 20 for 33 pass completions for over 265 yards. This week Tannehill will likely struggle with the passing game against this defense. Last week, The Bills allowed nearly 190 passing yards and gave up nearly 10 first downs by passing. The Buffalo Bills will likely be looking to put pressure on Ryan Tannehill in the pocket. Tannehill will be able to utilize his legs and scramble out of any danger when necessary.

Derrick Henry will carry the majority of the run game for The Titans. Last week Henry had nearly 4.0 yards per carry and should be able to keep up with that pace.

Robert Woods, Kyle Philips, Nick Westbrook-Ikhine, and Austin Hooper will be responsible for receiving for The Titans. Last week Robert Woods had 2.0 targets, his usage should be higher this week, and he should be able to connect much more. Last week Nick Westbrook-Ikhine had 2.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week Austin Hooper had 2.0 targets, his usage should be higher this week, and he should be able to connect much more.

Josh Allen will lead The Bills on the offense. Last week Allen went 26 for 31 pass completions for nearly 295 yards. This week Allen should be able to keep up with last week’s passing performance. Last week, The Titans allowed almost 160 passing yards and gave up nearly 10 first downs by passing. The Tennessee Titans will likely be looking to attack Josh Allen in the pocket. Allen should be able to use his speed and mobility to run the ball himself.

Devin Singletary will carry the majority of the run game for The Bills.

The Bills will have Stefon Diggs, Gabe Davis, Dawson Knox, and Isaiah McKenzie handling the receiving. Gabe Davis had 4.0 receptions last week but should see more usage in this matchup. Dawson Knox had over 0.0 receptions last week but should see much more usage in this matchup. Isaiah McKenzie had 2.0 receptions last week but should see more usage in this matchup.

Minnesota Vikings vs. Philadelphia Eagles

Kickoff: Monday, September 19 at 8:30 PM EST

Point Spread: 2.0

Over/Under Game Total: 50.5

The Minnesota Vikings will face off against the Philadelphia Eagles at Lincoln Financial Field this week. The Eagles are favorites at home, getting 2.0 points from Vegas.

Kirk Cousins will lead The Vikings on the offense. Last week Cousins went 23 for 32 pass completions for over 275 yards. This week Cousins should be able to keep up with last week’s passing performance. Last week, The Eagles allowed nearly 200 passing yards and gave up nearly 10 first downs by passing.

Dalvin Cook will carry the majority of the run game for The Vikings.

The Vikings will have Justin Jefferson, Adam Thielen, K.J. Osborn, and Irv Smith Jr. handling the receiving. Last week Adam Thielen had 4.0 targets. His usage should be higher this week, and he should be able to connect much more. Last week K.J. Osborn saw 4.0 targets. Ideally, he’ll get about the same number of looks this week. Last week Irv Smith Jr. had 2.0 targets; his usage should be higher this week, and he should be able to connect much more.

Jalen Hurts will lead The Eagles on the offense. Last week Hurts went 18 for 32 pass completions for almost 245 yards. This week Hurts should be able to keep up with last week’s passing performance. Last week, The Vikings allowed nearly 230 passing yards and gave up over 10 first downs by passing. The Minnesota Vikings will likely be looking to attack Jalen Hurts in the pocket. Hurts should be able to use his speed and agility to run the ball himself.

Miles Sanders will carry the majority of the run game for The Eagles.

The Eagles will have A.J. Brown, DeVonta Smith, and Dallas Goedert handling the receiving. DeVonta Smith had 0.0 receptions last week but should see much more usage in this matchup. Dallas Goedert had nearly 2.0 receptions last week but should see more usage in this matchup.